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Im not quite sure what all the sulking is about ISA TBH. We have a large corporate that uses it, two boxes one with RSA on and the other without. Both are pptp connections, forced 128bit enc, nothing lower allowed, MS-Chap V2. Both run on DL360's, 2.8gig, single proc, two gig in one and three gig of mem in the other (the RSA agent runs away with memory and they've never fixed it).
Currently the none RSA one has 143 users on, has an evening peak of around 300 and has been up since 28 Dec when it was last re-booted for patching. Prior to that is has been up for months and has to my knowledge never crashed. Isa 2004 standard in use, they hide behind ASA's (personal paranoia) and they are also used as outbound web proxies for 1200ish on one and 14-1500 on the other. The none RSA one is currently doing between 10 and 20meg average about 13meg, most of which will be remote users as there are few in the office today. Processor running <10%.
Assuming you have a decent domain security policy (i.e. high strength passwords, changed regularly etc) I would have no hesitation in recommending it for 250 concurrent users..
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