I'd love to see a control panel for running a multi-domain email only server, with decent spam and virus filtering built in, without a per user or per domain license.
A panel to control of php 5 / mysql 5 / ruby-on-rails etc server would be nice - the latest technologies seem to be lacking from the big control panels.
Good luck with your plan - I'd be thinking about helping if I had more time (feel free to pm me as a beta tester when you're getting there